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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Paeonol, Cisplatin
Phytochemical Name Paeonol (PubChem CID: 11092 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 864
Ref_1
Pair Name Paeonol, Cisplatin
Disease Info [ICD-11: 2C94.Z] Bladder cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression CASP3 hsa836
In Vitro Model SEG-1 Lung large cell carcinoma Homo sapiens (Human) CVCL_8113
Eca-109 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_6898
Result Paeonol, in combination with cisplatin, had a significantly synergistic growth-inhibitory effect on oesophageal cell line, which may be related to apoptosis induction
03. Reference
No. Title Href
1 Synergistic effect of paeonol and cisplatin on oesophageal cancer cell lines. Dig Liver Dis. 2008 Jul;40(7):531-9. doi: 10.1016/j.dld.2008.01.012. Click
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